USE SPOILER TAGS YOU FUCK. JESUS.
Short of some really egregious betrayal of character there is no way Nero (who I'm pretty sure has a non-binary gender identity and seems to prefer they/them pronouns, though they never preach at anybody about it or spell it out in so many words) would become a couple with him. Nero just gets more and more pissed at him over the course of the game as the interviews pretty much confirm every bad assumption they have about him. At the very end when he mentions how Fertech owns him Nero is almost sympathetic for a moment, but then Reed goes and confirms that Nero's initial assumption about his motivations from the opening monologue was completely correct, even using the exact same words.
Not even gonna talk about how relationships transform all the time and just because somebody doesn't like somebody else now, it doesn't mean it will remain that way in the future. Honestly, it's like I am reading kid post.
Nero doesn't hate Brandon, she hates what Brandon represents and what he does. But even if she hated him, it doesn't mean she cannot fix him. Truly spoken like a guy who has never seen a girl end up with a guy that she disliked originally.
I intentionally didn't use a spoiler tag, so that people can search for solution easily. If it's hidden in spoiler tag, it won't come out in search results. And this thread is going to grow bigger quickly going forward and my reply will get buried. So mostly people who look for the solution to the puzzle will see it.