Somewhat but not entirely.
Netori happens by default for Jessica and Gwen. You can technically not sleep with Madison though Arc keeps forgetting that's an option
. The Side Girls are optional.
You can minimize it but you can't completely avoid it. Arc has a very hard time with branching paths.
Maybe
Luna can be avoided at the moment but I'm not sure if she will need to be maxed to get to Act III later on. And at some point Arc tends to forget he let the player choose not to do something. Really has a hard time with branching paths...
While I like Kana and Annie they weren't essential in Act I but you had to gather the entire Scooby Doo gang to progress.
As for generic prostitutes well you don't have to pay them or mind control them.
I'm going to make some assumptions on this since the phrasing seems off...
Unlike Ravager the only fetish content you can control in Options is Pregnancy and Yandere.
Lesbian content - There isn't an option to turn that specifically off but Arc also hasn't put a lot of effort into that content. You see two girls playing with each other in Luna's route.
Other guys with girls - Besides the very brief moment with Luna & her attendant (technically son in the code) along with Chastity and the only man she ever slept with in an old porno there isn't anything major with this either.
There are a few threesome scenes with the player and two girls. I think you can say no to most of these.