I don't know if we're having the same problem, but whenever I have my G8 characters look at a null (or any other object) they don't adjust properly until I move the character or the null/object. Then, once I save the scene and open it again later they are no longer looking at the object anymore.
I've found that once I have everything positioned how I want it, I'll make a note of the "rotation" parameters for the character then remove the "points at" and manually adjust the parameters back to what they were. This way they characters are still looking where I need them to be when I open the scene to render.
It's a pain, but it works. So, if we are in the same boat, then hopefully it helps. Otherwise, ignore my post.
If anyone else has any better ideas, I'm open to hearing them.