I think the big cliffhanger will be related to one of our earlier choices. Specifically when we meet the Founder at the Galla, he ask if the MC "fight for himself or for others" as well as if he "would sacrifice love one for power".
There are a few other things that comes to mind. Consequences of the "heist" in real life. Axel making true on his promise early in the game, to make Orion's life living hell and target his live ones. Luna's uncle's carter business, as well Raul and Noal dealing with the mafia, resulting in the girls being under crossfire. Final one is that "the aliens appear on earth and begins to target everyone" leading to orion scrambling to find them and save them. The last one is the most unlikely, to be honest.
Well, he would most likely scramble to save them no matter what. The question is if he would "succeed and be hero" or "fail only to visit Eternum and find that not only their spirit/soul are there but he can also bring them IRL".