Is hard to say from the top of my head an accurate list because every character could involve different activities in victory or lose, are condicioned by what you wear and your stats and randomness. Like The Demoness, will fuck your ass with her heels if you loose to her, if you have a plug she could decide to use your mouth in her pussy if you aren't gagged or ride you (humiliating you if she consider your penis is not big enough for pleasure her) if you aren't caged and steal your soul cursing you unlocking the succubuss class. However you could don't see any of this content with this NPC if the demoness is friendly to you or you win. She is a female character who will pee your face if you have watersports activated.
Verbal abuse is a fetish you should enjoy or being neutral to play the game. Unfriendly NPC will humiliate you and feel pity, being disgusted by you and shame you and could react to even your clothes, toys , body writing and mental or physical stats (they could focus in your penis size and making fun of you ). Involuntary body modification in the forms of tattoos, branding, piercings or even cosmetic implants take place in the game, could be considered hardcore for some players. Pee and semen is a common topic, and even you could activate diapers content (is deactivated by default). I don't recall foot worshipping or scat are shown in the game but there are some facesitting and ass/pussy eating to female NPCs.
The dominatrix in the Mansion level is a NPC focused in the classic english styled discipline femdom. Sadism as fetish is a rare content in the game.
Here you can find a not updated wiki of the game, to check what actually what content you can filter/enhance in the game. Sex with males is not in the list to filter.
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Here there are list of all NPC (the school is not listed so is not updated) and any possible interaction with them
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If you want to play the game looking for femdom experience you will be disappointed. Secretary is a better choice if you look for an dominant strong woman more powerful than the protagonist slowly feminizing him without magically become crazy for cock. You could spend several hours playing without having any kind of sex with males.
Perverted education have the option to substitute males with transwomen but isn't a very polished option.
As you said is possible to make a femdom feminization evolving to a lezdom game without the MC touching a single male in the whole game. Sicco's games fill the bill. Theoricaly is also possible to have a feminization game without chastity content but is almost an standard write in stone in this games.