Yes, reading is hard....
Regardless, all old mods can work with a newer game version, but the never must work with a newer game version. So, if the patch isn't affected from the newer game version (eg. only small grammar correction) then it mostly would work. Often wait for the modder to assure you that the patch will work for the newer game version too.
The old mod mod will not work with the newer version of Harem Hotel.
Runey made changes in the earlier part of the game that conflict with the old mod and caused crashes, as early as day 2 that you cannot get past.
I went through that on version 16.0 because I was starting over again, and installed the old mod, under the assumption that it should be fine with the old content. I could install the new mod when it was released.
Day 2, entering either Kali's room or Lin's room I got unrecoverable errors that involved clothing items that had not yet appeared in the game.
Deleting the entire game folder and re extracting the game, without using the mod worked perfectly.