It probably depends on the choices you make. In my play through Jerome will have his way with all of the women. After all, that is his goal. The wife is #1 on his (my) list.
I'd also like to see Ricky (the weird kid) have sex with the wife. He's been missing in action for awhile though.
In terms of the husband, I'd expect him to not take things well. I don't see him as a weak cuck, but with him being handicapped what can he really do.
Side note.. I am hoping for a scene where Jerome rolls the husband outside the house in front of a window and locks him out. As a sick gift, he gives the husband a birds eye view of him fucking his a wife hard. The husband is enraged but helpless to do anything about it. Kind of dark, but that's the game we're playing.