I have been using "C:\Games\HoneySelect2" for my HS2 directory for over 2 years and it has never given me a problem loading. C drive is a 1TB NVMe drive, 1/3 of it used.... if you move your "HoneySelect2 R14" directly under C:\ (out of subfolder "Games" - makes the file pathes unnecessary longer) and also shorten your main folder to HS2-R14 maybe you get better loading performance.
And do you have no other drive? On C:\ may occur conflicts with the operating system (normally only if you use system folders like "Program Files", but who knows?).