And if it's another Nyx dead end, like dating Layla and Alexis at the same time
There's already one dead end, if you start flirting with her on a Layla playthrough she just never engages...
Funny enough since you brought that up... if you lie to Layla and Alexis, Valeria learns about this and also keeps her distance, figuring out you are bad news.
I don't think she's gonna be a complete void, there's gonna be something... even if later some curveballs show up, mother problems, ex-boyfriend from out of town...
People need to let go of that "confirmed LI list" that's from years ago and Nyx changes her mind every 10s.
And i'm pretty sure that list never mentioned Gabi or Iris who i've boinked a couple of times.
So even if by some weird parameters that only Nyx knows what they she's "not a LI", there's a big chance that there will be fun stuff with her still.