Alexis has some juicy drama, on a Alexis run you can have:
Erynn and Iris are horny as hell, they want to be with the MC just as much as on their solo paths... but because you are dating their friend they haven't pulled the trigger yet, very personal to them, they are always close, girls giving sad jealous looks... with more on the way(the poster).
Valeria, who has met Alexis through Layla, demands that you end the relationship to continue with you... but you can lie to both of them and see how that plays out

And of course you probably fucked her cousin Lakeyin in a flashback.
Nikki/Cara also can be combined but there's 0 interactions so far, still waiting for something.
Same with Gabi and Melissa, possible to combo but no interactions.
And Tori, it's possible to bang her on the beach in the middle of a date with Alexis.
Layla+Elena are the only characters that get fully blocked by Alexis.
Until Layla decides it's her time to backstab