Having one of: "Slam" "Cleave" or "Skewer" certainly helps.man cant even get past that first orc boss
do i have to focus on combat skills first or some shit?
Also, unless you're doing a no-corruption run, buy one of the cheaper accessories to boost your primary stat (the attack type you intend to use the most).
Third and final, go to the room with 0 or very low fatigue, and possibly take out the Thugs in the lower part of the room first, or they show up in the bossfight later.
If that isn't enough, I'd recommend learning the game mechanics first.