What I do is, first research basic medical application and stick that on a serum with primitive serum trait for the trait slot, then research that to have it available on the production line.Ingenious equation, really. High level economics.
But seriously. If I don't hire any employees, I can make just barely enough stuff to break even. If I hire any employees at all, I cannot make enough to break even. I've tried this four or five times and went belly-up every time. What SHOULD the profit margin be on an early serum? The highest I've been able to get is 70.
Next, hire two employees, one that generates 30 something supply per turn, and one that generates 30 something production per turn. Their salary should be in the 30-something per day range. Save scumming is your friend here if you don't get the employees you like when selecting to hire new employees.
Stick them on their respective areas, make them produce the basic medical serum, and sell whatever they produce every day. Be sure to do some HR work every now and then to keep your company's efficiency up. Investing points in charisma at the start of the game should make HR work easy, though honestly I'm not even sure if the extra charisma is even necessary as far as HR work goes.
Hiring an extra pair will increase profit, and so will investing some money in serum production policies for better efficiency at production.
PS: On a different note, the arousal suppression serum trait is bugged as hell and maxed out Stephanie's core sluttiness in a couple of turns.