Not sure if it's a hardware issue (on renpy? I've only seen this on other engines!) but, some of those character animations were causing me window-wide black or white flashes for a fraction of a second. I'm no expert, but those were pretty rough on my tired eyes, might actually be a seizure risk to someone prone. The secondary character profile menu was giving me black flashes (possibly related to the character shadow?), and one of the screens in the shop (I think the room itself?) was giving me white flashes.
Haven't checked out any content in the slums yet, so no comment if any other areas have this.
Despite the issue, it's a strong start, left me hungry for more story and characters. It's been a while since I've last found an in-dev renpy game I was excited for the future of. The quick access to stat-based scenes does feel a bit rushed, but it's nice to have them available instead of just 'implemented but inaccessible'.