The problem with not being able to change the color of clothing is still there, which makes them look terrible. A pink top and green bottom are ugly. Also, the clothing stores almost NEVER have the good clothing, but always have the business stuff and grandma dresses.
I think you can change the colors of the default clothing? I mean, the ones you choose to wear at the beginning of the game. But yes, you have to visit dozens of clothing stores to find the "right" clothing and color combination. Maybe the dev could split the generic clothing stores into specialized clothing stores: sports, casual, business, and have each clothing store carry all the clothes and color combinations within their category.
Also, it would be nice to have some sort of "automatic clothes changing" option and/or a bonus/penalty for wearing the right clothes at the right time in the right place. e.g. you start the game with a specific look, say, business, and if you want to go to the gym you have to buy sports clothes, if you want to go clubbing you have to buy casual clothes, and so on. Better (more expensive) clothes could give a boost to specific actions (lifting weight with expensive sport clothes gives you a 20% boost to muscles and fitness, working with expensive business clothes gives you a 20% boost to job experience, performance etcetera) instead of permanent bonuses like it is now.
Speaking of bugs, I noticed the NPCs rarely (never?) wear any shoes.
On an unrelated note, I played the game without mods for the first time and was shocked to see that you can't buy condoms? How can you avoid STDs? Well, chastity aside...

I know there's the experimental vaccine perk, but it costs 3 points, and to get the points you have to do something naughty, so it's a sort of catch 22...