I think in general the choice of a poison heavy deck puts you at disadvantage against the raging enemies (demons and minotaur princes), because they tend to aggro very quickly. If you don't kill them by end of board 1, board 2 is going to be messy.Just finished v0.4.5b. Great update. The only issue I ran into was that it seems like the drop rate on regular ingredients is too low. Other than the days that I trained sword fighting, I hunted in elsewhere every day that it was possible to do so and ended the game with a total of less than 40 ingredients having never sold any so it wasn't possible to get the perfect gem with them.
I have gotten enough in previous playthroughs so maybe I just got unlucky. I also had Bella along with me most of the time once she became available and took every opportunity to use her help when looking for treasure and also to grab the 5 extra moves from the camp fire.
As far as balance, I think the Minotaur princes may have been buffed up too much. That automatic rage boost they get builds up so fast that for me at least they were entirely unkillable. That was the only opponent I couldn't beat. I had around 50 strength, intelligence, and charisma as well as 20 swordsmanship by the end and still couldn't kill them.
Unlike in previous versions I found Dylan to be quite useful in the latest version since shields no longer block poison. For the same reason I found Poison to be the most reliable means of dealing damage since nothing seems to be immune to it, it cuts through shields, and it's not affected by the damage reduction from ice either.
I found Katie less useful than before due to immunities. Bella was pretty much a permanent member of the team once I got access to her. Other than using her to upgrade Dylan, I still didn't find Emily to be as strong as some of the others but that may just be my choice of gems.
Dylan's actually a bit OP once Emily teaches him the regen ability, since it heals a percentage of your health (and as such scales with your strength).
Apart from that, you can also load the end of act IV save-game, and continue playing in Game+ mode (so no story events triggering, but you have unlimited days), which retains Emily's new attack and Bella's new reusable crossbow bolt.