The game does not open is loading a minute and then it closes what do I do?
Try to be a little more patient. By me the loading screen sometimes disappear for a min. before the game actually starts.
Another reason could be if you have unpacked the script files using unren. Unren doesn't work with the newer renpy versions, and gives sometimes weird errors.
If that doesn't help, you could try to delete the persistent files. They are located multiple places <game root>/game/saves, users/*my name*/AppData/Roaming/Renpy/MCR2 and also users/*my name*/AppData/Roaming/Renpy/MCR2/sync . If you have played the old version too, you should also delete the persistent files in the MCR game folder.
By deleting the persistent files, you will loose your unlocked galleries etc, but you won't loose your save files.