I'm really not sure how this game has been here for so long and I am only now noticing and trying it.
Then again, I know that Titanium was discovered in the 1790s - a century or two after Europeans "settled" in the Great Plains - and about a decade before Louis & Clark's Expedition went through that area.
So, there's that.
Perhaps this story will integrate "The Wasp" with the mass fatalities and "unintentional" genocide of the 1837 Great Plains smallpox epidemic. That would be a plausible time for the Titanium and English, while still before the Hunter Process of 1910 (when nearly pure Titanium could be produced in batches in labs) as well as before the Kroll Process of 1932/1940 (1932 it began production outside the lab, and 1940 began commercial production.)
Either way, I am well past that point in the story and this seems quite interesting so far.