In this game? Sure. Ian can easily interact with every girl and not hit on them, he has various scenes with Lena and Holly just talking about art, career and life. Or hanging out with Emma along Perry and Wade, drinking, playing pool and chatting. Or helping Cindy and Wade in an entirely friendly way (snide remarks incoming). Consequently, they don't flirt with him as soon as they know he isn't interested, with some exceptions like Alison or Gillian.
With Lena, most guys are noticable more forward and only interested in sex, that leaves Ian and his gang (Perry, Wade) and I suppose she can remain friends with Stan, even if she has to turn him down (supposedly he moves on...).
So your fears mostly align with Lena, who barely can have a male friend without drama, but don't with Ian, who can treat every girl just as a friend.