Unless you're running both games at the same time it should be a non-issue; I guess you could have a situation where opening PL2 while PL1 had access to the system.sav file, but even that should be a write and release thing, not a continuous write one.Update 2: Didn't do anything, yet, but I did research the error itself. From what I found, it apparently happens two processes use the same path. It could be that Paradise Lust 2 (As I had this problem there too, but wrote it off as the new game being buggy), since it is meant to share the same file with the first game, I think it might be the root of the issue. It could be that playing the new game caused some kind of error that now persists, even if both games were to be removed. This is just guessing work, really.
The error happens when the system can't get write access to a file; that could be happening because the folder/files are read-only, it could happen because there is a corruption in the disk system (
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), it could happen because another file has exclusive write access to it atm. In this case I'd do a disk check to make sure you don't have any bad sectors overlapping that space, and I'd go to the save game folder as your current user and make sure you have write access to all the save files.