I'm not sure what all was added from 3.4.3, other than a change to the look of the game stats screen and inventory. But I did notice that when I loaded my save, I was missing 5 titles. All 4 from the Gods and the Incorruptible title. Is there a way to restore these, as I don't want to grind all the titles again if I have to start over.
Nice catch, but I think it's only a visual glitch, they don't show when you appraisal in your room, mine didn't either, but the veriables seem to be in place correctly, and if you kill yourself and check the panel that appears on revival, it's there:
Dumbledore, Explorer, Conqueror and Saint are all here for me, and the Incorruptible, and our parents talk also include all those.
TL;DR: It's a visual bug, you probably didn't lose any of those titles
On another note, I found the visual overhaul really good, the best part is that list of titles you'll acquire on the suicide menu, removes a lot of guesswork.
Other than that, this update I think included a new mechanic with Kermit, I'm soul box level 9 and when I suicided to test, a new mechanic that opens up a permanent shop appeared, it uses Kermit coins, that can be gotten trough doing achievements, basically by playing and doing other shit.
It has quite the cool and op features, like changing the opening day of Threadbare from 150 to like 31, a bunch of strong items and three perks, lowering the requirements to level up titles all the way to 69% of the original, chance of super rare chests up to 30% and ten extra slots on the soul box.