Alright, I managed to do virgin run on lewdicrous difficulty as proof of concept. Basically, with power of save-reloads, luck and knowledge. Just use skills smartly to reduce chances of bind and always save either 'divine blast' or 'all strength'. Not letting ailments stockpile helps too.
Make sure to hoard cure ailments on floor 1 with power of savescum and repetition. Approximately 20 of each remedy will be needed for full run, 8-10 roses, clean water, cloth fix and 3-5 peaches should cover all needs. Bosses can be cheezed by abusing 'icy water of repose', get some too. I prefer to get turtle shell and pair it with chest or rice ball to get maximum quantity of encounters before bosses. Even with chest, it let's you get crucial lvl thresholds for skills and forms.
Icy water, paralysis immune, turtle shell and chests/rice balls you can get only from stage 2, on stage 3 upgraded chest and rice ball, on stage 4(blue/gray ominous ruins) you can get first ice inflicting talisman, must have. Also you can't summon full immune mirror here, but i got it as regular battle reward on this stage somehow. Rest of stages not matter too much.
Seal skills of bosses per cd(if you did not and you got hypno-dased, then binded and graped, that's an end, F5 button reloads game to main screen), use paralysis immune charm and 'protect yourself' move to endure deadly combo-wombo. And use remedy and salve before battle.
Also, seal every suspicious enemy-use common sense to determine if dude gonna just hit hard or inflict ailments like a gatling gun. If it's slime/tentacles/some geometric something, seal it 24/7. If it's humanoid, it probably gonna just wrestle you(which easily divine blasted). Robots are 50/50. Can be tank, can be pervert. Also read names-if some "lewd/corrupting/hypno/etc" then seal even if humanoid. Also berserk form+horn+dagger can 2-3 shot enemy most of the time.
Here savefile as proof but 1 item "not letting enemy cum" got eaten by game bug, there 2 "super anti-heat drugs" now. I guess you shall conquer last 7 extra stage without opening chests in gallery beforehand, good grief.