Here's my somewhat attempt at a "Guide" for those interested, based on what I've learned and know so far, this is just my assessment after playing around for awhile.
Don't waste any of your money on buying items for charm, appearance/ looks, lust/ lewdness etc. If you do buy any items just get the energy drinks.
Don't waste any of your money on upgrading the three main girls, I would argue it's a waste of money because there's not too big of an emphasis on their shared skills. If you upgrade them, just get the big major exclusive to themselves skills, if you do upgrade their shared skills ("Shared Skills" such as Care, Flirt, Take Out, and Send Text/ Exchanging Contact Info with Clients). It's best that if you do upgrade those Shared Skills, don't bother trying to max them out, just get one point in each if you must. Otherwise just focus on Upgrading Rai's, Cookie's & Cynthia's Independent skills.
- For Cynthia, upgrade Synth-IA (when it becomes available) it's not completely necessary but at least the Maids will check out clients by themselves without you having to click on them. Focus more particularly on upgrading her Distraction & Just A Number skills.
- For Cookie, upgrade 3Cookie, Book of Secrets, Foresight, and Apologetic.
- For Rai, upgrade Mind Break & Menacing Presence
Again, if you MUST upgrade any of their Shared Skills, don't bother dumping too much money in them, just one skill point in each is enough.
The point to highlight here is that Ame becomes your SUPER MAID, she's literally your biggest money grind mega milker. Your three other Main Maid girls can just sit in the Back Rooms all day because once Ame's skills are maxed out there's almost no reason at all that you don't end a day without raking in between 6k-14k depending on what clients enter the cafe during the day.
((Edit: In fact, this is partly the only reason it might be completely and totally unnecessary to even bother upgrading Cynthia's Synth-IA skill upgrade, because this would give you optimal time to check out all clients without a stressful hassle of cycling Ame onto the clients on time before they check themselves out. So in my eyes, Synth-IA is an almost completely useless skill, it makes no sense at all to begin with that clients don't check themselves out unless Cynthia gets that Synth-IA skill but meh, it is what it is.))
((((((Dev, if you're reading, at the very least understand some points to this from the perspective of those playing your game. You're doing a good job and I appreciate your efforts.))))))
Don't waste needlessly on drag & dropping a clients orders, just enough to keep them "Happy" so their gray bar goes green, then remain green by letting an order remain unfulfilled (basically if they ask for a Hotdog, drag & drop the hotdog to get their Happiness meter to go from grey to green, then wait until they want another order of Coffee/ Tea/ whatever & just don't fulfill that order), then let them stay there until they're ready to check out. If you have Synth-IA skill, you'll have to hurry & be quick enough to check them out with Ame and don't forget to cycle between the customer/ clients with her, this is how you get maximized profit from Ame's skills.
- For Ame, upgrade her Lone Wolf & Stalker skills to max.
- For Ame, because she is your SUPER MAID, I would stress more heavily to focus on upgrading her "Shared Skills" such as Care, Flirt, Take Out & Send Text after upgrading her Lone Wolf & Stalker skills maxed out.
- For Ame, use her own Benefit that benefits herself being alone with Sergil in the Cafe.
Ame's Stalker skill is the reason why it's unnecessary for you to buy items for appearance, charm, and lewdness, because she's basically a Klepto, she will bring Sergil a random item once per day, maxing out the Stalker skill just increases the chance that she randomly gives Sergil a more rare item. If you're worried about leveling up a Maids appearance, charm, lewdness etc. then the best way to do it is just have Ame bring in those random items daily since it also saves your money.
I would rotate the other three main girls around the Back Room to clean in the closet and the other two to just sit and rest in the break room, you rotate them between the closet to clean and the break room because the one cleaning will gradually lose their energy.
Again, focusing on increase Ame's skills as your highest priority is what gives you your fastest money making grind thus far from what I've seen. It's literally your best and fastest way to make money.
As for what clients to tend to based on money making priority, I would focus more heavily on saving and only using the Care skill on the Lonely Housewife client, whom gives the largest tips but slow to order and fast sit time. There's also a blue haired client, he gives increased tips depending on how high the Maids Lewdness factor is. After that it's the Jock, just have Cynthia tend to him with Care and he gives her the bigger tips.
Out of all the clients the Cafe gets so far, those main three clients (House Wife, Jock, and blue haired guy), are the best choices to increase your tip money faster when you actually fulfill their orders. The other clients give such a low amount of tip money it's almost not worth fulfilling their orders, just once is enough to make them happy and no more than that.
That's about the best advice I can give for a "Guide" so far. Once Ame is maxed out, to increase your money making grind faster, upgrade Cynthia, Rai, and Cookie for the Glory Hole and/ or the VIP rooms. It's also strongly recommended to max out the Break Room & Closet Backrooms first, and then use Ame to save enough money after that to pick up the Career, Promo rooms for the Idea Points so you can have the little mini-camera for the Glory Hole room. Again, doing this there shouldn't be any problems making around 6k to 14k per day depending on what clients show up for Ame to tend to.
edit: Also, using Ame as your lone maid in the Cafe, she's the best at upgrading Sergils Cafe skills as well.