Try to have all the girls you can interact with in your base, do everything you can do to them so you can have all of their content (generally its end when you unlock ''slut'' outfits).
To max profit, put the non interactive girls to work, level them up and put them to work in higher roles on the club or the bordelo, remeber to always change their role to maximaise your gain, because you start to gain less according to time.
For the villans, always have someone doing a haist and don't waste the best ones doing this work, use them principally on quest haist
Look in the security part of your base( I dont remenber if the threat level is already working) put your villans to work doing security on your business, it will give you some bonus, recommend you put a girl to protect Lex Corp so you can have a scene with her on the bedroom. Change the Hench Woman dependly on the girl you will visit (ex: Galatea for Supergirl, Harley Quinn for Louis Lane)
There are some other hints that I dont remenber now