I think I get what you mean? With this game Cis, Fatima, and Anna are supposed to be the three big main female love interests that get the most focus, and then there are the many side characters who have their own stories but on a smaller scale.
But with the way season 2 has been set up, Fatima was the only one out of the three who was getting consistent development during week 1, while Anna got just a few teases in the missions and Cis was largely absent until the very end of the week. They end up having the same presence in the story as the secondary characters, if not less then some, like Diana and Sarge. I think is just all a symptom of the mission structure season 2 has, though.
Now that I think about it, and this may kind of be related as to why a lot of the male characters are more popular, there is a bit of a difference with how a lot of the male and female 'romances' are being written. The most popular male characters, the ones winning the polls and the ones I see getting constantly brought up in the comments (Sam, Cole, Chad, Drex, Rick), are also the ones receiving a lot of romantic development that is very gradual, a slow-burn that focuses on their seduction by the MC, so there is more anticipation and build-up when things do eventually escalate; which makes sense, they all start out as 'straight', and the story needs to justify why they are "ditching the bitch and making the switch", so to speak. (actually them all being 'straight' might also be a very big reason behind their popularity, probably not a coincidence, but I think the romantic writing is definitely a factor too!)
This is absolutely not the case for the majority of the female cast who are all immediately down to fuck, skipping right past the seduction phase, which is not bad, but there's just immediately less to look forward to and get invested in for future updates and story developments. The big exceptions of course are Anna and Cis, and they are the ones I see being the most popular on here.
Might be a tad overthinking it, though.