heya (again). sorry if i was short before on the response. the friggen character limit had me struggling with trying to answer your question on that profile page so apologies if i appeared abbreviated or short with ya. wasn't my intention.
So I'll give ya 2 answers: a shorter one and then a detailed one and you can pick whichever one you prefer.
short answer: in most cases, whether you choose bathroom, shower, homework, or tv, it shouldn't impact the overall story. you won't miss large chunks or things like that. many of those choices simply just give you extra events or could stimulate a conversation, background, information, or maybe other conversation choices that pop up later in the story for continuity. but it won't affect the overall story. the only choice that affects the overall story majority is the pervy vs respect route choice at night when zack has a choice whether to peek while braden is sleeping or not.
long answer: so everything above still applies here obviously but this version of the game is also a "revamp" of the original. while i've never written a story or coded a game before, i tried out a few things during the original game and some of those worked and maybe some didn't as much. however, it was important to me and to many of the fans to not change things in the revamp from the original so i took that seriously. In the original game, when you had multiple choices, there were certain orders that could unlock a progression forward in the story. so you kinda had to figure out the right combination as the days scrolled through. when i was working on the revamp, i didn't like this mechanic at all so i eliminated it and made things more linear. however, all the conversation choices and stuff still remain to keep things original so if you were a fan of all the homework bonding stuff, you could still do that and not affect the story, or if you liked the goofy stuff that happened during tv events, you could still do that. the bathroom was kinda different. some people may find bathroom content uncomfortable so i wanted to make sure all of those events at the urinal were avoidable. there are other conversations that get unlocked as a result of those choices but many are background information, stories from their past, or just other insights into their personalities.
for example, in one scene, if you choose the bathroom, there's a conversation about pranks which unlocks a story about bullies from braden's past in the cafeteria later but those don't have an impact on the overall story.
imo, you would not have to play through all the choices because it's pretty minimal in how they affect the story. basically, i have pretty serious concentration issues so trying to juggle multiple storylines in my first project was pretty overwhelming, so i stuck to a more linear story with a few choices here and there to do what you want to provide opportunity for extra events.
hopefully, that's the answers you were looking for. if not, you can ask follow-ups. i tend to ramble