I think by the time MC reaches level 4, the Twins will have found ways to coexist that will be fully agreeable with them. Perhaps we may get a chance to separate them but I think their condition is here to stay for the vast majority of the game.
Also their condition is very complex, Tanos is probably a level 4 and an advanced one (so whatever he did to them has more chances to "stick" for longer, if it's anything like Duncan's situation) and we don't even know how Deryl will manage to evolve.
Perhaps at level 5 MC may be able to do it at will, but level 4 seems a bit hard to me
These are the colewin points:
1. Starting the fight with >= 500 Power
2. Choosing to fight level 3 Cole with Memory powers
3. Running away from level 4 Cole
4. Having >= 40 skill after the last brawling scene
colewin >= 3: MC slaps Cole by himself
colewin == 2: MC slaps Cole with Deryl's assistance who manages to shoot him once and distract him
colewin <= 1: MC tries to slap Cole but Cole has enough power to launch a final heat based attack, killing MC