Hmmm... In Kirito's case, it might be a very good fit. Although I don't know how Kirito's condition can be called "ignorance." Sometimes it seems that he consciously ignore all the information around him. It's like Kirito isn't ignorant at all, but rather detached. Kirito is the embodiment of three Buddhist monkeys - "see no evil, hear no evil, speak no evil"
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I think that here you can also use the phrase said, according to legend, by King Solomon - "For much wisdom is much vexation, and he who increases knowledge increases sorrow." The excess knowledge about Suguha will only bring Kirito pain and suffering.