JokerLeader's mod changes things in the game, and my mod changes even more things. If you play and save the game with a mod installed, there's a good chance that save may then become beholden to that mod and incompatible without it, or at least a version of it. It sometimes takes me a while, but I'm usually good about updating my mod between game updates. Playing the game only with mods means not just having to wait for the main game's developers to update the game to play it, but for the modders to as well.