I think its too late for Natasha to have any kind of meaning.
(I'm happy to be proven wrong)
It might have been meant to show her trying to regain control of her life,
while showing whats been eating away at her. (possibly just to cap off her story)
It seems like to us, her story has been neglected for a while but given the actual time frame of the game (not that long).
Her absence makes sense.
She was away for long enough to dwell in negative feelings and come out of it seeking something.
What that is time will tell if we find out or if she just vanishes.
I would bet we seen the last of her.
otronegro
I'm pretty sure Angel is a safe bet and she seems to have no connection to anyone out side Monica for work.
However I've always been of mind the MC should just move and start a new life.
Everyone there as I have said before, is so easily willing to do questionable things.
Sell homes, move away.
Start over.
Anyone follows you, fault cant be put on the MC.
He said screw you, I'm going home.... To a new home!