It may not count as a cliffhanger or really a twist, but it was definitely the first moment in the game where I was truly surprised:
Vinny pulling out a gun on Fuckface.
Before that, we had only seen a gun one time and it was in a flashback sequence when Rox gets mad for the rat comment made by that MacGuffin character (whose name I didn't care to remember) to little Quinn. At that moment it was just a device to show how dangerous Rox really was and the fucked up nature of Quinn's childhood.
When Vinny uses it, again it is being used to show how dangerous he is. But then the shock of the moment wasn't really what he did, so much as who he did it to(reading through before posting and I realized with one sentence I made Fuckface sound like John Wick
). Prior to that scene, I expected him to be carrying but I didn't expect him to show it to the MC so soon in the story nor to pull it out when he did. If anything I expected it to be used on Tommy to get him to let Vinny snoop in the DIK mansion. The fact that no one else even gets a hint of the gun before Fuckface surprised the fuck out of me.
It didn't do much yet to the plot but it definitely served as a reminder that though the vibe is brighter than AL the stakes are very much the same.