nope.
you can only advance after seeing every event possible, than doyle will become a viseble ghost, and not just a voice.
when that happens, you can choise the path you want them to be. (only 2 posiblilety's except for mia, no path alteration as of now) you can get more content with the girls and have them react difrend, or stay the way they are now, no new content for them, or changes in dialog.
everything depends on the amount of scenes you have unlocked. (mia can never take your V-Card unfortuanly, as you need to lose it before she spawns)