Possibly, but it'd be difficult without knowing what to do. It's very easy to make a wrong choice and get Chloe raped. But as far as I can remember, I don't think any sex scene is mandatory, per say. There are event chains where you go through steps/stages, so you could avoid the ones with men in them. Girls sometimes bring their boyfriends into the action in some, so be wary no matter how lesbian a path seems. You can probably get by making the right choices and ducking out if a boy gets involved in the third stage of an event, for example.
Again, might be a good idea to look at an unlocked gallery or guide if there is one. That way you can keep it all lesbian. Just don't follow that story anymore if men get involved. As far as I remember, in new updates it won't prevent you from seeing the new stuff if you chose not to complete everything. It's all new event chains, prerequisites are usually items or outfits you can buy.