I'm a decent chunk through my current run (about to fight Love), and will probably have more thoughts when done as I've decided to do a few things different this run: I've focused on creating a bunch of Succubi from Lillith's Awakening, which had its own complications of delaying distortions until after T4 INN in most cases, but mechanically: MegaloSplendor (which is a hilarious fight with new despair condition), Despair (with breaks) Victory, MegaloReign (although letting her run free to see how bad her loop 21+ fights are) and soon to be MegaloLove to finally kick Splendor from the position. I haven't skipped any loops.
But here's a lot of rambling for now:
1. I didn't go into the run with the intention to use it, but I've had fun with Mobile Dungeon and an Aversion Undead.
I use Day 1 to train the "virgin" Undead with Drain Soul, leading to a gain of 75 or so EE which is enough to buy 'Networked Consciousness' and deploy a Tempt forsaken for Day 2. Then reset her memories if I want to train again for a bunch more EE OR need to do a Raid to inflict billions of ANGST in order to get a good baseline of damage, lock chosen into higher downtime actions or get enough to Negotiate to counter annoying Angels stealing it.
It's also the first time I realised what Strategic Advantage does when you let the chosen get the buff.
2. Despair Victory is working decently, although I do wish I could make her more expensive. The base price is 17 EE after breaking T4 DIG for the +trauma buff, but I could/would easily pay more in almost all cases. With that punisher effect, INJU/EXPO feels the best style as PLEA/INJU/EXPO seems a bit weak. Doesn't lead to the longest second surround, but tends to hit 7/10 or so which is decent enough. The first chosen captured has the MegaloReign buff and future ones have the first chosen's EXPO levels.
I haven't had much use for her defiler 'Regroup', but having 1400 extermination with no items and only a bunch of spared is kinda nice as a passive.
Oh speaking of her defiler, it doesn't have an actual name in the forsaken list - Just repeats her style instead.
I believe she'll end up as a vastly superior Second-In-Command than if you simply put her there via Megalomaniac, as the passive and option to buff her trauma damage feels better than +50% to bosses. I'll see when fighting 21+ Loop Reign I guess, but I don't have prior experience to compare to.
3. Splendor is a jerk as always when you leave her as the Second-in-Command, but she has been fairly good at keeping the spot warm. She's my go-to forsaken to farm Devil punisher progress and she's also fun to send at Victory just to hear them bicker at each other.