Everything is up to date; window 10 and AMD Radeon R5 (yes it very old)
2017 isn't very old. Up until last fall, I was running Windows 10 and NVIDIA GeForce GT 630 and I was able to run this (v0.05.5, obviously).
That said, this is the minimum requirements for games made with RPG MZ:
OS: Microsoft Windows® 8.1/10 (64bit)
Processor: Intel Core i3-4340 or better
Memory: 8 GB RAM
Graphics: Compatible OpenGL / VRAM 1GB or better
Additional Notes: 1280x768 or better Display
It appears the AMD Radeon R5 is an integrated graphics card - one person had a problem with an integrated card, while another had to switch to using their integrated card, in order to play the game.
I would make sure that the drivers you have for the video card are from AMD, directly and not a Windows Update... just in case.
Best of luck.