When you get close to completing all of the Episode 2 quests (except the Marcus quest), check out the
FAQ (point 1.3.5). Also there is a chance that you will be able to use the Ctrl key to
fast-forward through most of the dialogues you have already seen before. This will help reduce the time it takes to play the game again.
This is not the first time I've seen reports of a player not saving the game (or saving very infrequently), relying only on autosave and encountering problems as a result. and having problems as a result. So I now added info to the very beginning of the FAQ about the need for more frequent game saves.
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