I hate to be the one to say this, but 'Skill Issue'.There is also no player skill factor so you can't make up for bad RNG by playing well.
Sure, there are some runs that are lemons, that's part of the design philosophy of Rogue Likes. But to say there's no player skill factor just means that you haven't fully understood the game's systems. Strategy makes a huge difference in how well you do in any individual run.