Blessing a sword or shield will give you better chances at hitting and evading, respectfully. A ring of regeneration or vampirism will help with hp, as long as you manage her intake of cum. Also, let the enemies move into range to attack you when they close. It consistently gives you the first hit and can save you from taking more damage in the long run.
Getting an early bronze sword and blessing it can be very useful if you find a fountain. Even with the negative to hit from stats, you are still rolling twice to hit an enemy.
Altars help with finding out if stuff is cursed or not, as well as telling you how many shots are in a wand. I haven't really found a good reason to bless rings and I haven't noticed much of a boost from it in any of my own games. Enhancing a ring to a +1 (or more) will boost its effect, which is lovely for certain item drops.
Also, a wand of enhancement seems to be a permanent effect. Casting it into a mirror is an easy way to get some stat boosts.
Played a metric ton of rogue-likes in my day, so I hope that helps!