I don't really see the walkthrough. I'm having a lot of trouble figuring out what I should do. What is the main gameplay loop? What is the main quest? I see that going to the classrooms increase the numbers at the top. Should I constantly pop into the classrooms?
Talking to people and doing their requests give no feedback to the player to know that that actually accomplishes anything.
Some sense of direction would be nice.
Your character, whether male, female, or futa, has some issues with sexy things. Your goal should be the total corruption of Smallville. You can do it in several ways. There are drugs you can make if you build the chem lab. Read the books you can find around the game and you can learn some hypnotism skills and use them on the NPCs. Look for the newspaper and read it. Play the intro at least once since there is a bunch of useful information there. On the map is a help button that has more useful information. Visit the detective and start some investigations.
Keep the school small at first since your cash is limited, then when your rep moves up, start adding students. Open some clubs as that has a bunch of the corruption paths. I like to get as many students into school as soon as I can to work on a bigger population as soon as possible. Early goals are to corrupt your teachers and the PTA to allow more depraved policies to be put in place. That will lead to the school becoming more to your liking.
There are very few things that are presented to you that don't more the story forward. Learn the things that help or hurt your reputation and try to keep your rep up in the 70s-80s. Work out to up your stamina and appearance since it will help with your interactions with the NPCs. Don't forget to bathe.
There are three sets of numbers in the game that are important but you can only see two of them. The first is your stats which you can see when you hover over your name in the lower right corner. The second is the school hive mind stats which are displayed across the top. That is a collection of your enrolled students stats. The third the the town hive mind which you don't have any access to in the game. You can get into a place where your school is way more corrupt than the town as a whole and that can hurt your reputation.
I would say that a willingness to be as depraved as possible with your MC is a good way to play. Understand that as you have more success, most characters will say they love you but will still be having sex with anything that moves, most you can't see, but if you have your sister come live with you, she will be bringing over "friends" more often.
There are only a couple "game over" events, everything else is recoverable. The game is big and it will take several times before you get the hang of it and decide on your path through the game.