Most other games / engines you just search for the actual value of the variable you want to change. For example if you have 5000 gold in a total war game, you search for 5000.
The 2N+1 is specific to RPGmaker games made with a version of RPGmaker from before RPGmaker MV. So VXAce, VX, XP, exc. So it'll work on at least some (not all) of the games with the RPGM tag in the thread title. RPGmaker MV uses a different method that cheat engine doesn't really work with AFAIK.
You can tell if it's one of the older RPGmaker engines if it has a game.ini text file that looks something like this when you open it.
[Game]
Library=System\RGSS301.dll
Scripts=Data\Scripts.rvdata2
Title=Ideology in Friction - Append v1.02
Unity is a separate engine entirely, and should work with just searching the variable as is. You may need to change the scan settings depending on the engine and game. Honestly, if it's for anything mainstream (IE not porn) you can often find "trainers" which are files you can load in cheat engine to automate the search, have various cheats and the like you can select from a list, and a lot of ease of use things for those of us who don't have the time or knowledge to figure everything out.
You do need to be careful with cheat engine, since it's changing actual data for the current instance of the game, so you can seriously mess things up. So keep a backup save if it's something you're worried about risking losing and never do anything to the main system programs.
