Speaking as a big fan of harem stories, I concede Becca's and Amy's personalities and backgrounds do not seem any prone to show open-mindedness to polyamorous or open relationships, nor Melody seems any likely to have a positive reaction to the perspective of incestous flings with aunt (especially with her surrogate mother bond with Amy and her idealization of her dead mother). On the other hand, Melody did show potential to embrace polyamorous experimentation, as long as it based on a sufficient foundation of trust, friendship, and bi erotic attraction. As of last update, she is already eager to have the man of her life and her BFF with benefits in the same bed, the horny minx. The story built all the right premises for the MC and the college trio to jump into polyamory with both feets within a couple updates. I guess next update shall be dedicated part to give Amy and Becca's stories a proper happy ending, part to consolidate the MC/Melody/Sophia relationship, part to keep building up their professional success. The update after that shall likely be focused on integrating Xianne in the group relationship to some degree, and give the threesome/foursome and main couple paths their happy endings.
As it concerns Izzy, IMO she had pretty much all the right personality features to belong in the harem as a relatively typical childhood friend, I assume she would have formed a sister-wife (or more if she has any bi leanings) bond with the college trio without any real difficulty, but unfortunately the story deprived her (and us) of any real chance to meet and befriend Melody and her friends. A pity since I guess they would have gotten along great. I fear it might be far too late in the game's development cycle to correct course. Of course I would be most pleased and delighted if the developer team surprises me and finds a way to make her a last-minute addition to the harem, but I try to rein my expectations on this. Also because due her work committments, Izzy's role in the harem would be not be much more than a recurrent visitor.
After all, even Xianne is far too busy to be with the rest of the group all or even most of the time, unlike the MC, Em, and Fi trio whose career and romantic paths mix wonderfully. Unless she finds a way to belong in Melody's professional team; perhaps she might be her personal masseur, since so far she has shown no sign of having musical talent. Or perhaps, since she is suggested to have talent as an erotic dancer, she might retrain to become a dancer for Melody's performances.
By the way, I know so far Melody's career has been built up to be a solo singer/songwriter, but I see no good reason why her, Sophia, and the MC could and should not change course and form a kickass band. After all, professional musicians switch from solo to band and back again all the time. I think the story would feel all the more fulfilling if the happy threesome becomes professionally bonded as a successful band as well, besides the MC being manager/boyfriend to both girls.