I was able to make a rpy that makes a generic change to swap landlady to mom and roommate to sister, however, there were several lines in which the mom refers to Bob as 'the landlord', and other stuff to the point I don't think the replacer works with more than 1 word. Also, the release on F95 as a patch2.rpy/rpyc, the game won't recognize them as a valid patch until it gets renamed to patch.rpy.There is specifically code in there that attempts to detect a patch.rpy Once it does it changes the names. I works for the original content but i havent (obviously) tested it for the new content. i dont think it will work on new stuff.
I've attached what little I've done, using a blatantly ripped code from a renpy forum post.