Regarding a few Pandora questions, every question regarding will it work with X Nemesis or Y FNIS or a combination of said mods the answer will be yes in 99 per cent of cases, the specific question regarding precision creatures, yes it works, currently using it along with a few other Nemesis mods that require creature compatibility, and yes, it all works with my degenerate animal mods from FNIS if you're asking.
As for the XPMSE patch, the latest XPMSE version comes in two formats Lite and Full so grab the corresponding XMPSE patch for Pandora.
The set up for MO2 is the same as with Nemesis designate an output MOD/Folder remember to disable FNIS and Nemesis including there corresponding output folders and creature behaviour files etc, launch the tool from within MO2 like you would Nemesis and tick the patches you require, in this instance you can pretty much tick everything because there're no superfluous patches outside of the mods you've already installed hit launch and everything should be patched up in about 30 seconds.
I assume whatever process was used to installed Nemesis through Vortex will be the exact same process for Pandora but i cannot speak to it.