You don't need to use UnRen to activate dialogue skipping as the game lets you do that anyway from the settings menu, so that might be causing the problem.
Like I said in the post that
Hero1 mentioned, don't use UnRen for anything. If you follow the steps I laid out in this other
post, you should have a smooth playthrough.
OK, that seems to be a valid finding. However, I always restricted rollback in my mod to not skip day time transitions, location changes and major FSM transitions. Basically, I do not see any harm in skipping back dialogs when nothing than displaying dialog lines happened.
I admit I also had some issues with states getting lost, but not so many (in fact only one issue that I never could reproduce since, namely that one that forces you back to the beginning when having completed the first day). I assume that could also have been because I developed my mod in parallel, loading a save on multiple versions of the source I modified.
After that happened to me, I only saved while in the main city map, and I completed first Eve's story alone (only few other story parts), then everything else more or less in parallel.
What I want to say: I feel that rolling back with the restrictions I mentioned should be safe.
On the other hand, nothing I encountered and nothing what you mention explains why older safes also seem to become corrupted. That is also something I never encountered myself, but people keep mentioning here...