Personally, I'm most looking forward to the extra NCHDL missions, combat overhaul, more powers, and extra Institute content. More combat options in particular would be nice to give some reason to focus any real effort on physical stats. Right now I can't really think of anything you really need physical stats higher than 2 for other than the reflex check with Mom in the shower.
Finishing all the school girls would be nice but I'm more interested in seeing him add things like Villains, especially if it's female villains that use sex related powers against you. Or maybe male villains that do things to some of the girls if you don't stop them. Would also be nice to see some Institute missions that require some sort of interaction/combat/etc rather than just an influence boost with no interaction. Would be nice to have some fun with the 2 Institute Enforcer chicks as well.