-OUT OF DATE AND WRONG. I'm a fucking idiot and mis-read the tooltip for Vitae Generators, they actually only cost -1 Green Fuel per tick, and their output can be doubled by integrating a human into them, though I suspect this also doubles their input making them count as two generators with the capacity of one. There are no images for a human-integrated Vitae Generator though, so you'll need to make do with placeholders or make your own.
So... I did some math, and would like to run my findings by the forum for lolz. These values are per tick and I have no testing to back these figures up.
One Red Fuel Generator: +3 Red fuel, -3 Green fuel.
One Green Fuel Generator: +3 Green Fuel, -1 Red Fuel, -1 Biomass.
Biomass Generator: +2 Biomass, -1 Red Fuel.
Liquid Pump: -1 Red Fuel.
The mathematically optimal power plant, using one Biomass Tree, one Pump, and two generators of each flavor, only produces +2 Red Fuel per tick.
But it gets worse. Remember how you need Drones to transfer Biomass to the Green Generator? Let's assume that five Drones can supply two power Generators, and ignore how you can't actually do this since the Neurotissue Plant doesn't work. You'd need to build a Zone Source and Drone Synapse, each costing -1 Red Fuel.
In the vaccum of space, a perfectly optimal power plant can sustain... itself. The Synxens need to switch to solar power.
Now. It is theoretically possible to actually make a profit, again, pretending that Neurotissue Plants work. The Heart of the Hive produces its own Control Zone, that's +1 Red Fuel. If you can build a Behavior Node, which again, YOU CAN'T, you can turn humans into free biomatter plants at a rate of two humans per plant. This is technically a wash, since you need the Node to run the Milking behavior into a Drone Synapse to make it actually function, but there is wiggle room here depending on how many human biomass plants five drones can run. For each extra plant five drones can operate, again, in a perfect world with no travel time and the ability to directly order your drones, that's +1 Red Fuel, and remember, we assumed earlier that five drones can supply two structures with Biomass.
In a perfect world, assuming Drones are smart, that the Neurotissue Plant works, which I cannot stress enough, IT DOES NOT, and the unaccounted for X-Factor of how much Biomass drones transfer per tick, cutting the second Pump from the equation as it isn't strictly necessary, with 22 structures all of which cost Resin, Biomass, and sometimes Neurotissues, with 21 veins and 4 nerves, you reach the dizzying heights of +3 Red Fuel per tick, enough for the Neurotissue and Resin plants you'd need to actually try this shit.
Or. You can just accept your Heart of the Hive will produce +3 Red Fuel per tick, accounting for the two spent on the mandatory pump and Incubator, and running buildings only when you need their services. You might not even go insane if we pretend the Neurotissue plant works (IT FUCKING DOESN'T AAAAAHHH) and can use Nerve Switches to turn off buildings instead of manually connecting and disconnecting pipes. Most buildings will cost one, Acid Plants cost two as they need their own Green Fuel generator to function, and the Artisan costs two as you need a Behavior Node to switch your drones into the Crafting Behavior, which again costs Neurotissue, so keep pretending. Be frugal, be careful, pretend the Neurotissue plant works, and in about six thousand years, maybe you'll actually beat the game.
Or just glue your dick into the queen's womb, spend all three on Biomass plants, and drown the strategy board in zerglings until everything fucking dies. That's probably a lot easier, I should've started with that.