I mean, it's not really clear if humans interacting with vampires is inherently dangerous for the humans. There are a few examples, where that's not the case, like with Alys, detective Grimes, Naziim and Shevaun. Outcasts like Zoey and the PC don't really have a choice and need to work with humans, but even Elliot has to be in the public eye as a CEO.
Of course Claire is not supposed to know about vampires and it gets more and more difficult to hide the closer you get to her. But we don't know, yet, if this game has a strict law like the masquerade from the inspirational material. That's only an assumption.
True, but I'd argue that by our very existence, they are in danger. However, that danger is proportional to the knowledge gained eg. with zero knowledge they are usually safe from permanent harm. With knowledge, they are on the kill, or worse, list. Since we are a fledgling I would argue that every human that we come into contact with is in immediate danger, so unless we are saving their lives or the equivalent, or feeding, we should not interact with them until we get enough knowledge to keep things in check.
From the gameplay perspective, with the new skill system, which accounts for the % of ALL skill points in a category you could have gotten up until that point, being locked from a quest feels like a kick in the balls. I have no knowledge if I permanently fucked my char by not making the correct decision, as maybe these 2 (for now, more later) quests turn out to be heavy on skill checks, which directly translates to my character now not being able to pass skill checks in the future.
But, perhaps I misunderstood the new skill system and it does not take into account quests that you did not do, in which case everything is gucci.