Vector features are a godsend. It's the main reason for the slowdown of the scene I'm working on, I'm transitioning from sketchbook to Clip studio paint. Having to learn/relearn a whole new control scheme, but "redraw vector line" "simplify", "adjust width", "move control point" all make animation a matter of a few button presses. I'll have to check out inkscape though, as if I don't have enough drawing programs.
If I read correctly, paint.net will be adding tablet/pressure sensitivity soon, which is super exciting. Free open source ftw