This has gone from fun to mess around in a bit glitchy but stable to completely unplayable. Some mechanics that worked in previous versions are broken or seem to be gone.
The inventory menu barely works anymore. You can't scroll through the skill list, the tool tips that explain skill bonusses are gone and sometimes the hotbar glitches out and you can't remove items from the first two slots anymore. (also it's been gone for a while but where did the perk points go?)
Loading into or out of a zone partially resets your levels. (I was messing around with the cheat menu, you seem to keep part of your levels but they drop by 50. Which is very harsh if you're playing legit.)
Doing basically anything locks your quests but the game is in such a terrible state you'd be mad to even try. The tutorial quest chain which was glitchy but completable is now gets stuck on returning after crafting the spear.
You often get locked in a state where you can't interact with anything including your hotbar and items on the hotbar. The game seems to think you are talking to someone. This also includes saving your game, apparently you can't save while "talking".
It's now impossible to lure creatures into having sex with you by masturbating in combat. The only way to do so seems to be by defeat but if your levels are sufficiently high enough some creatures are physically incapable of downing you. (I did reach that state by cheating but it's very much possible legit)
Pregnancy does not seem to work anymore. Yes I did have it enabled.
Creatures spawned from babies are hostile. To be fair I did spawn in the babies from the cheat menu, since I couldn't get pregnancy to work, but I did then use the workbench to create the summon. It is immediately hostile.
I have yet to tame a creature by having sex with it. To be fair couldn't really test it extensively because getting downed is a pain in the ass but this is something that stopped working a couple of versions ago.
NPC's disappear, the only ones that don't seem affected are Isabella (since she's in a different cell) and the fisherman.
The character creator random button is completely fucked. It used to generate at least passible characters. Some still ugly as sin but at least they had an actual face structure.
And finally, after messing around for a while trying to get stuff to work, I could not exit the game through the menu. Had to tab out a close it like that.
(I didn't try building to much other stuff was going wrong)