So here's there thing, not all antiviruses are equal. Some are more accurate and reliable than others. This is important because not all antivirus programs on VirusTotal are reliable indicators of whether something is a virus. The other thing to be aware of is that some of these antiviruses aren't meant for personal computers. Industrial-grade antiviruses are more strict because a company's use of computers is generally more focused and limited and anything that's known to conflict with their chosen antivirus program are going to be whitelisted anyways.
Because of these two things, you shouldn't immediately freak out if you see one or even a few antiviruses flag a file. Ususally a low number of hits means it's a false positive. Find out if those antivirus programs are even reliable for what you're scanning. However, if a lot of them are flagging the file and even the well-known antivirses don't like the file, it's best to be cautious.
If you spend enough time on this site, you might pick up on some types of games being common candidates for false positives, like games that run on Godot, RPG Maker, and anything that makes use of text hooking to translate. That doesn't mean that these types of games are always safe, and the people downloading the files may not necessarily do their due diligence to ensure the file is safe. It's up to you to do your diligence to cross reference the VirusTotal results and make your best judgement. Try to look up whether the file it's flagging is commonly flagged as a false positive. Don't be lazy and assume that the first rando that answers your question actually knows whether something is a virus. If anything happens to your machine, you can only blame yourself.