I like to think Summer City (the setting of the game) is one big NTR, since anyone can be dosed almost anywhere with varies side-effects that makes one agreeable to random hookups. Even being a woman doesn't make one safe, since as a XC woman I was still able to take the Secretary pill and endure with it's work/pleasure side-effect. And if someone is willing to waste a pill at the club just for the chance of some bathroom fun, I got to believe there's a ton of x-change pills on the market for cheap.
Likely we see more NTR when Blues roll out in the game, with wives dosing husbands for a a little switch-up or threesomes.